CORIN CLIA Kit for Human(Homo sapiens) | EIAab.comCORIN CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CORIN(Gene name) > Human

CORIN (Gene name),

Atrial natriuretic peptide-converting enzyme (Protein name ), CORIN_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CORIN(CRN;TMPRSS10);

Protein name:

Atrial natriuretic peptide-converting enzyme;

Alternative:

Heart-specific serine proteinase ATC2;Corin;Transmembrane protease serine 10;Pro-ANP-converting enzyme;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.

Subcellular Location:

Cell membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

1042

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1042:

FGLTSWGSVC | FSKVLGPGVY | SNVSYFVEWI | KRQIYIQTFL | LN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:10699

Pfam:

PF01392

String:

Q9Y5Q5

SMR:

Q9Y5Q5

UniGene:

Hs.518618

STRING:

9606.ENSP00000273857

MIM:

605236

Uniprot:

Q9Y5Q5

FOR

ELISA Kit for Human Atrial natriuretic peptide-converting enzyme

Cat.:

E1930m

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Packing:

96T

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ELISA Kit for Human Atrial natriuretic peptide-converting enzyme

Cat.:

E1930h

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96T

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ELISA Kit for Human Atrial natriuretic peptide-converting enzyme

Cat.:

E1930r

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Packing:

96T

CLIA Kit for Human Atrial natriuretic peptide-converting enzyme

Cat.:

U1930r

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MSDS:

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Packing:

96T

CLIA Kit for Human Atrial natriuretic peptide-converting enzyme

Cat.:

U1930h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Atrial natriuretic peptide-converting enzyme

Cat.:

U1930m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Atrial natriuretic peptide-converting enzyme

Cat.:

P1930Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Atrial natriuretic peptide-converting enzyme

Cat.:

P1930Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Atrial natriuretic peptide-converting enzyme

Cat.:

P1930Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Atrial natriuretic peptide-converting enzyme

Protein for Human Atrial natriuretic peptide-converting enzyme

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart."
Yan W. , Sheng N. , Seto M. , Morser J. , Wu Q.
J. Biol. Chem.274:14926-14935(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS TYR-13 AND ARG-525
tissue: Heart.
2.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS TYR-13 AND ARG-525
4.

"Localization of the mosaic transmembrane serine protease corin to heart myocytes."
Hooper J.D. , Scarman A.L. , Clarke B.E. , Normyle J.F. , Antalis T.M.
Eur. J. Biochem.267:6931-6937(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 734-1040
tissue: Heart.
5.

"Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme."
Yan W. , Wu F. , Morser J. , Wu Q.
Proc. Natl. Acad. Sci. U.S.A.97:8525-8529(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-985
6.

"Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin."
Knappe S. , Wu F. , Masikat M.R. , Morser J. , Wu Q.
J. Biol. Chem.278:52363-52370(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVATION;MUTAGENESIS OF ARG-801 AND SER-985;BIOPHYSICOCHEMICAL PROPERTIES
7.

"Role of glycosylation in corin zymogen activation."
Liao X. , Wang W. , Chen S. , Wu Q.
J. Biol. Chem.282:27728-27735(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;GLYCOSYLATION;DISULFIDE BONDS
8.

"Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood."
Peleg A. , Jaffe A.S. , Hasin Y.
Clin. Chim. Acta409:85-89(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"Ectodomain shedding and autocleavage of the cardiac membrane protease corin."
Jiang J. , Wu S. , Wang W. , Chen S. , Peng J. , Zhang X. , Wu Q.
J. Biol. Chem.286:10066-10072(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING;MUTAGENESIS OF ARG-134; ARG-164; ARG-180; ARG-213; ARG-239; ARG-244; ARG-427; ARG-801 AND SER-985
10.

"Human corin isoforms with different cytoplasmic tails that alter cell surface targeting."
Qi X. , Jiang J. , Zhu M. , Wu Q.
J. Biol. Chem.286:20963-20969(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION;GLYCOSYLATION;MUTAGENESIS OF ASP-26 AND MET-30
11.

"Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy."
Cui Y. , Wang W. , Dong N. , Lou J. , Srinivasan D.K. , Cheng W. , Huang X. , Liu M. , Fang C. , Peng J. , Chen S. , Wu S. , Liu Z. , Dong L. , Zhou Y. , Wu Q.
Nature484:246-250(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN PEE5;TISSUE SPECIFICITY;VARIANTS PEE5 GLU-317 AND GLY-472
12.

"An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss."
Guipponi M. , Toh M.-Y. , Tan J. , Park D. , Hanson K. , Ballana E. , Kwong D. , Cannon P.Z.F. , Wu Q. , Gout A. , Delorenzi M. , Speed T.P. , Smith R.J.H. , Dahl H.-H.M. , Petersen M. , Teasdale R.D. , Estivill X. , Park W.J. , more...
Hum. Mutat.29:130-141(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-525

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